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Uncovering hidden disability in MS 

Historically, the Expanded Disability Status Scale (EDSS) has been the standard measure of disability in MS, both in clinical trials and the real-world clinical setting.1 However, neurologists involved in the management of patients with MS will be well aware that the EDSS focuses on walking and visible physical disability, making it a less than satisfactory tool for assessing overall disease progression [see NeurologyBytes article on clinical trial endpoints].

In a study of 1,865 outpatients with MS, pain had the biggest negative impact on perception of health, followed by gait dysfunction and