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In MS, time is brain

In all patients with multiple sclerosis (MS), the degeneration of neurons and axons leads to brain atrophy.1,2 The longer the patient is without diagnosis and effective treatment, the more of the brain and spinal cord that will be irreversibly lost (Figure 1).2

 

Figure 1.2 A theoretical example depicting brain atrophy rate in an untreated patient with MS and a healthy control. Accelerated brain atrophy starts at disease onset, in this case at the age of 25 years, and continues throughout the disease course if left untreated.