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Fertility does not seem to be impaired to a larger extent in women with MS, however, in Western countries 10–20% of all couples are affected [Gnoth et al, 2005]. Therefore both infertility and MS might just follow the same pattern as the wider population and as a consequence, some MS patients may seek to undergo ART. In recent years, several studies have evaluated the effects of ART on MS relapses, all of which reported an increase in the annual rate of relapse following ART. Because overall data have demonstrated a significant disease activity in MS patients after ART, patients considering ART treatment should be counselled by neurologists on this potential risk, discussing the r

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