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Migraine: emerging concepts in pathophysiology, burden of disease, and patient adherence and persistence on preventive therapy

Highlights from the Teva-sponsored symposium held at the European Headache Federation (EHF)

Congress|29 September 2018 | 14:00–15:00 | Florence, Italy

Professor Paolo Martelletti from Sapienza University of Rome, Italy, welcomed delegates to the symposium and introduced the panel of speakers to the audience.


Emerging concepts in migraine pathophysiology

Professor Rami Burstein, Harvard Medical School, USA


Professor Burstein started his presentation by discussing the role of the hypothalamus in migraine.1 He pointed out that in the headache phase of migraine, the hypothalamus is shown to play a role in mediating a range of symptoms, such as chest tightness and shortness of breath, in response to light signals arriving from the retina.1,2 In a review of the role of the trigeminovascular pathway in the pathophysiology of migraine, Professor Burstein highlighted that cortical spreading depression is a neural event that appears to underlie aura in migraine1,3, and that it is the activation of the trigeminovascular pathway that initiates headache.4