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The European Headache Federation, I am currently the President of this Federation, accounting for 38 societies interested across Europe in headache disorders published, or is going to publish in the next days, three different guidelines for the treatment and the management of the disorder. The first one, in my opinion the most important, is the second edition of the guidelines for the management of headache disorder for primary care. The second one is the guidelines on the treatment of chronic migraine with onabotulinum toxin. The third one is the management of migraine in general, generally speaking, with the new class of drugs. The real life of any drugs will show in the real-life activ