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Video Transcript

CGRP is a peptide which was discovered about 30 years ago.

Originally as a very strong vasodilator, but now we’ve learnt over the years that it is also very important in neuronal tissue.

It has an important neuromodulator, neurotransmission function, and we also have learnt, quite recently actually, that it might play an important role in migraine pathophysiology.

It’s expressed throughout the body, but most importantly in several structures in the brain and blood vessels which are relevant to migraine, so it’s at the brainstem, it’s at the trigeminal vascular system, which strongly suggests that it’s playing a role in migraine.

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